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Nat Rev Nephrol 13:605 Skov J (2014) Effects of GLP-1 in the Kidney
Naltrexone is an opioid antagonist originally used for addiction treatment
Histologically, ephelides have fewer melanocytes but have more melanosomes, which are larger in size
While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers
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