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In rare cases, persistent constipation may signal the need to lower your dose, switch to a different GLP-1 agent (such as semaglutide), or use a combination therapy like PlexusDx's GLP-Squared Injection

Bennett BJ, Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ: Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation

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However, further details are needed on how the pathway and its effects on other processes in plants