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These factors modulate the expression of key biosynthetic genes and the accumulation of specific polyphenols, and ultimately affect our ability to estimate their bioavailability, which could render ineffective polyphenol's therapeutic potential in human metabolism

Nat Meth 10:1922 Matheis K, Laurie D, Andriamandroso C, Arber N, Badimon L, Benain X, Bendjama K, Clavier I, Colman P, Firat H, Goepfert J, Hall S, Joos T, Kraus S, Kretschmer A, Merz M, Padro T, Planatscher H, Rossi A, Schneiderhan-Marra N, Schuppe-Koistinen I, Thomann P, Vidal J-M, Molac B (2011) A generic operational strategy to qualify translational safety biomarkers

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Stress management, cognitive behavioral therapy (CBT), and targeted supplements (like magnesium glycinate) can also help