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X-ray crystallographic studies have demonstrated that copper coordination occurs through the N-terminal amino group of glycine, the deprotonated peptide nitrogen of the Gly-His bond, and the imidazole nitrogen of histidine, forming a square-planar geometry characteristic of Cu(II) complexes

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It plays a vital role in controlling pigmentation & discoloration by inhibiting melanin production leading to clear and glowing skin

The first hypothesized mechanism is via the stimulation and secretion of the VEGF, leading to the growth of blood vessels in the area surrounding the hair follicles