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The primary function of the urea cycle is to process this excess ammonia into urea which can then be eliminated through excretion by the kidney

In addition, the anoxic microenvironment is beneficial for glycolysis and lactic acid production by key enzymes of glycolysis and lactate dehydrogenase A (LDH-A)

Under low testosterone levels, the expression of genes related to glucose transport is downregulated, including insulin receptor substrate 1 (IRS-1), insulin receptor subunit (IR-), glucose transporter 4 (GLUT4), AKT serine/threonine kinase-2 (AKT2), and solute carrier family 2 member 4 (SLC2A4) [150, 151]

A cobblestone effect, a variegated appearance of the grafts, and sinking pits represent potential unfavorable outcomes