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It is also known that acetate in the large intestine promotes the secretion of anorectic hormones such as PYY and GLP-1 from large intestinal L cells and leptin from adipocytes via GPR41 and GPR43 expressed in the intestinal epithelium 14
The takeaway from that table is the whole point of an honest comparison: the two rows with real strength each describe only one drug, the direct cagrilintide-vs-retatrutide row is empty, and the only cross-drug row is explicitly weak
While many patients pay less than $100/mo, others face higher costs
this effect is almost immediate when you start Wegovy
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