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More serious considerations discussed in prescribing information for GLP-1 class medications include potential effects on heart rate, pancreatitis risk, and contraindications related to personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
There is currently no NICE technology appraisal guidance on retatrutide, as the drug has not yet completed the regulatory and appraisal process
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