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PI3K/Akt/mTOR Signaling Cascade A primary downstream pathway of IGF-1R activation is the PI3K/Akt/mTOR cascade, which regulates cell survival, protein synthesis, and metabolic homeostasis
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, 273 , 30695-30703, Wilson, B
It is also being investigated for its potential benefits in cognitive function and as a supportive treatment during chemotherapy
Therefore, the tissue-specific effects of l-carnitine are likely to be different among species, and thus more low-carnitine animal models should be established to intensively evaluate the possible different functions of l-carnitine among species
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