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doi: 10.1016/j.cell.2011.02.013 46 NunesSCRamosCSantosIMendesCSilvaFVicenteJBet al

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However, despite proposed promising candidates such as inflammatory markers (e.g., IL-1, IL-6, TNF-) 5 , glutamate system alterations 6 , and metabolic dysfunction biomarkers 7,8,9 , the clinical use of biomarkers in psychiatry remains limited due to inconsistent protocols, patient parameters neglect, and population variability 7

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