Lower IGF-1 means reduced lean muscle preservation, slower collagen synthesis, impaired exercise recovery, and progressive changes to how the body partitions fat versus muscle
are a serious but common side effect of INCRELEX
Clinically, good progress can look like: Waist circumference reducing Better fasting glucose / HbA1c (especially for diabetes/prediabetes) Improved blood pressure and lipids Less snacking, fewer cravings, better satiety Better energy and sleep consistency Plateaus: why they happen and what to do A plateau is common after the initial phase because: Your body requires fewer calories at a lower weight Hunger signals can adapt over time Activity levels sometimes drop (subconsciously) when intake is lower What helps plateaus most: Strength training 24x/week Higher protein (discuss target with your clinician/dietitian) Consistent steps or low-intensity movement Fixing hidden calories (liquid calories, weekend drift) Reviewing dose tolerance and meal patterns with your clinician Plateau doesnt mean the medication stopped working. It often means the plan needs an upgrade

In this study, people were given just 18 mg of quinine, or placebo, and then, an hour later, everyone was given all-you-can-eat ham-and-cheese sandwiches