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A glutathione deficiency therefore leads to the activation of von Willebrand factor and the accumulation of ROS, which affect coagulation and platelet activation , impair endothelial function and predispose to the risk of thrombotic events , in particular hypercoagulation

Thus, considerations of doseresponse relationships derived from epidemiologic studies concerning the health effects of arsenic in drinking water should include the likelihood that the dose derived from drinking water alone does not represent the total arsenic dose

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