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Additionally, although morphological staging has historically been used, there is currently insufficient evidence to determine disease severity based solely on appearance, and no validated symptom-based staging system is available.3 Despite this, lipedema is commonly described based on two classification systems: distribution types and morphological stages

To date, no clear clinical evidence has suggested a tumorigenic effect of GLP-1 RAs [24-26], yet the steadily increasing use of these agents worldwide emphasizes the importance of thoroughly evaluating their potential association with cancer risk

GLP-1R activation modulates postprandial insulin secretion, delays gastric emptying, and engages central appetite circuits

For example, a study found that two-thirds of tested expired drugs maintained stability for months or even years after expiration