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But the doses required (typically 5001,500 mg of berberine per day) are far beyond what a small patch can plausibly deliver through the skin, even before you account for the absorption barrier
doi: 10.1056/NEJMoa2307563 200 JastreboffAMAronneLJAhmadNNWhartonSConneryLAlvesBet al
The results were compelling: GLP-1 RAs significantly reduced the risks of major adverse cardiac events (MACE), kidney disease progression, and even overall mortality
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This intermediate dose provides a stepping stone for individuals progressing toward higher maintenance doses
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