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The GIP hormone enhances this action of GLP-1 which leads to even greater results in both appetite/portion control and weight loss
Dual GIP/GLP-1 agonists like tirzepatide 15 mg achieve approximately 22.5% average weight loss over 72 weeks
Possible relation to pancreatitis or pancreatic adenocarcinoma Another type of study of the exocrine pancreas has been to give GLP-1 mimetics or DPP-4 inhibitors to animals over a prolonged period of time and evaluate the pancreas for evidence of pancreatitis or precancerous lesions
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