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Additionally, patients taking immunosuppressive medications may have altered responses to infections, and any medication causing significant gastrointestinal symptoms could affect absorption of oral immunosuppressants

Although the findings in the CANVAS trial showed a higher risk of amputation when taking canafliglozin compared to placebo [92], no significant difference in the risk of this complication was observed in the CREDENCE study [88]

Research also shows that IGF-1 LR3 activates the PI3K/Akt/mTOR pathway