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FDA Guidance for Industry and FDA Staff
In hypothyroidism, about 15 20% of patients report fatigue or brain fog even after correction of thyroxine levels to normal with levothyroxine (2528)
Injecting slowly, over 20 to 30 seconds rather than in a single rapid push, allows the surrounding subcutaneous tissue more time to equilibrate as the solution is introduced
Funding This work was supported by grants from the National Natural Science Foundation of China (NSFC Numbers 81672800, 81603009, 81673020, 81802632, and 82173830), Natural Science Foundation of Shaanxi (2020JQ-445), and the Key Research and Development Program of Shaanxi Province (2021SF-207, 2021SF-223, and 2022ZDLSF05-19)
