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EUR20.73 EUR62.73

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Tirzepatide, compared to both GLP-1 and NNC0090-2746, shows biased signaling at GLP-1R, favoring cAMP response over -arrestin recruitment, which leads to low efficacy for GLP-1R internalization (108110)

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Pregnancy, breastfeeding, and severe renal/hepatic dysfunction also require avoidance or specialist consultation

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HuYZhangYHeJRaoHZhangDShenZet al

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