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Unlike stimulant-based appetite suppressants that cause sudden appetite loss, semaglutides gradual approach leads to more sustainable, long-term weight management
For context on the broader class, SURMOUNT studied the GIP/GLP-1 dual agonist tirzepatide for weight management (NEJM 2022) and SURMOUNT-OSA studied tirzepatide for obstructive sleep apnea (NEJM 2024)
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The 44% fatigue rate at week four of 2.4mg dropping to 22% by week eight is a useful frame: the first month of any new dose is the hardest
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