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Nonetheless, BBB opening raised several concerns such as potential brain toxicity due to the non-specific accumulation of neurotoxic substances from the blood that could produce neuronal damage and degenerative changes (Han, 2021)

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For example, reduced levels of SCFAs (like butyrate, which is normally made by good bacteria) can weaken the BBB, making the brain more vulnerable to harmful substances

Here are the most common ones: The most common semaglutide side effects, which are nausea, appetite changes, and digestive discomfort, are systemic