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IGF-1 LR3 Research Applications The most established application of IGF-1 LR3 is as a growth factor supplement in serum-free mammalian cell culture, where Morris and Schmid (Biotechnology Progress, 2000) compared LongR3 against insulin in CHO lines expressing recombinant proteins, and where it is widely used as an insulin replacement at much lower concentrations

High insulin levels can contribute to atherosclerosis (hardening and narrowing of the arteries), high blood pressure, and abnormal lipid profiles (elevated triglycerides and decreased HDL cholesterol), all of which are risk factors for heart disease and stroke

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Metformin has been shown to have some anti-inflammatory effects in clinical studies in patients with T2DM, in experimental studies in rodent models of obesity and T2DM, and in vitro experiments with several immune cells (Foretz et al., 2019