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FOXO4-DRI is a novel peptide derived from the forkhead box O (FOXO) transcription factor, which plays a critical role in regulating cellular stress responses, apoptosis, and longevity
The peptide does not bind to a single identified receptor but instead modulates several biological systems simultaneously
After two years, homocysteine levels in those who received a supplement with 200 mcg of folic acid, 10 mcg of B 12 , and 10 mg of B 6 had decreased by 2.4 mol/L, or about 17%, more than placebo, and bone mineral density loss had slowed in a subset of participants with low baseline B 12 status
It mimics the naturally occurring incretin hormone GLP-1
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