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Although inhibition of PDH activity by overproducing pyruvate dehydrogenase kinase 4 in INS-1 cells did not affect GSIS [35], it is possible that PDH may play a supportive role for GSIS by providing acetyl-CoA to condense with the oxaloacetate produced by PC, to form citrate for downstream shuttles
doi:10.1210/clinem/dgaa863 29
10.1038/s41569-020-00435-x 2
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