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The FDA found no clinical evidence supporting wound healing, no adequate toxicology, uncertain product identity and a potential immunogenicity risk with injection

Gong et al., 2021

Because insulin resistance in PCOS is a whole-body phenomenon expressed most strongly in skeletal muscle, liver, and adipose tissue, and retatrutides three signals converge on exactly those tissues indirectly, by driving large reductions in body weight and ectopic (especially hepatic) fat, and possibly directly, through incretin effects on the pancreatic islet and on adipose biology

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