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Currently, two FDA-approved GLP-1 receptor agonists are directly derived from the Gila monster venom peptide exendin-4: exenatide (Byetta) and exenatide extended-release (Bydureon, Bydureon BCise)

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Cancer / proliferation concern: Potentiating c-Met (a proto-oncogene product) raises a legitimate theoretical risk of promoting pre-existing or nascent malignancy

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