The results by maintenance dose were as follows: 5mg/week Maintenance Dose: Resulted in an average weight loss of 16.0% with over 85% of participants losing more than 5% of their body weight and 32% losing over 20% 10mg/week Maintenance Dose: Resulted in an average weight loss of 21.4% with over 89% of participants losing more than 5% of their body weight and 50% losing over 20% 1 5mg/week Maintenance Dose: Resulted in an average weight loss of 22.5% with over 91% of participants losing more than 5% of their body weight and 57% losing over 20% Placebo: Resulted in an average weight loss of 2.4% with 35% of participants losing more than 5% of their body weight and only 3% losing over 20% Source: Jastreboff et al., SURMOUNT-1, NEJM 2022
Severe, constant pain, fever, or jaundice can signal cholecystitis or a blocked bile duct and need urgent evaluation
A specific target of 2.5-3.0 L of fluid daily, with at least 500 mL containing electrolytes (oral rehydration solutions, electrolyte tablets, or diluted sports drinks), provides measurable guidance
Lonardo A, Nascimbeni F, Mantovani A, Targher G