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After 8 weeks of treatment, the weight decreased by -1.4-3.3kg (122)
The development of next-generation oral GLP-1 agents with improved bioavailability enabling the higher systemic drug exposures needed to match injectable efficacy is the key technical milestone that will determine how much of the injectable market oral formulations can ultimately capture
Special considerations: Some GLP-1 drugs have specific timing needs
Nausea occurs in approximately 1525% of users during initial administration but typically resolves within 72 hours as tachyphylaxis develops
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