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10.1016/j.cellimm.2023.104778 130 JamasbiE.MularskiA.SeparovicF
In immune cells, PGE2 signals through Ptger4 to modulate the functions of T lymphocytes and dendritic cells, promoting Th1 cell differentiation and enhancing IL23driven Th17 cell amplification in vitro
In particular, exendin-4 was discovered in the secretions of the venom glands of the Arizona gila monster (Heloderma suspectum), which actively interacts with human GLP-1 receptors while being resistant to the action of DPP-4 The effects of GPP-1, GIP, and their inactivation by the enzyme DPP-4, leading to short-term action, are described above
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