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The authors framed the data as first clear evidence that NNMT inhibitors constitute a viable pharmacological approach to enhance regenerative capacity in aged skeletal muscle
Standard ranges fail to identify patients with subclinical vitamin B12 deficiency (which means many patients may not have full-blown symptoms of vitamin B12 deficiency but they do experience some) 3
The dosing schedule should be determined by a healthcare provider, with periodic monitoring of vitamin B levels and clinical symptoms to adjust therapy as needed
Some practitioners employ intermediate dose increases, such as escalating by 0.25 mg increments rather than doubling doses, to improve tolerance in sensitive patients
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