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Pretreating hepatocytes with IDN-7314, a pan-caspase inhibitor, impaired the TF activity and inhibit the coagulation activation in vitro and in vivo ( 4.3.2 Inhibition of the innate immune system The innate immune system, including complement system, cytokines, and innate immune cells, functions downstream of coagulation system and determines transplanted hepatocytes viability
Upon arrival at UTMB, the 18-week-old mice were single-housed and provided ad libitum access to water and a Western diet (WD
Not FDA-approved for human use it's categorized as a research chemical
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