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Its medical use is experimental or off-label
This reaction effectively diverts nicotinamide away from the NAD+ salvage pathway, reducing the cell's capacity to regenerate NAD+
Specifically, the enhanced infiltration of cytotoxic T cells, Natural Killer cells and anti-tumor macrophages (M1 macrophages) in 7.16.4 mAb/Cpt1a-inhibited tumors aligns with their role in tumor elimination, including ADCC engagement, in ErbB2+ breast cancer, where their presence may correlate with favorable outcomes 83,84,85,86
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