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At the genomic level, Epitalon modulated the expression of key circadian rhythm genes: Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased by 2.1-fold, all with statistical significance
1999 May;16(4):219-29
As burnout sets in, levels of serotonin and dopamine often drop, which makes restful sleep and daily motivation harder to keep up
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