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A meta-analysis of 24 weight-loss intervention studies (N=2,284) found that a 10 kg reduction in body weight raised total testosterone by approximately 2.9 nmol/L and SHBG by 5.7 nmol/L in men with obesity [3]

A recent mechanistic study using LDL receptordeficient mice and ox-LDLchallenged human endothelial cells demonstrated that liraglutide, one of the most widely studied GLP-1RAs, directly improves endothelial function by suppressing oxidative and inflammatory pathways ( in vitro experiments showed that liraglutide mitigated oxLDL-induced endothelial injury by suppressing NOX4 and NF-B signaling, and downregulating ICAM-1 and VCAM-1 expression (14)