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For class-level context, see DPP-4 Inhibitors and Weight Loss
These compounding factors mean standard weight-loss approaches frequently fail until thyroid function is optimized with medication like levothyroxine or synthetic thyroid hormone replacement
The estimated annual cost of providing GLP-1RAs to all indicated patients would be $3.35 to $5.31 billion at pre-generic 2025 semaglutide prices
However, in individuals with insulin resistance, appetite suppression alone often does not fully correct the underlying metabolic imbalance
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