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Abstract Background Parkinson's disease is a neurodegenerative disorder characterized pathologically by the loss of nigrostriatal dopamine neurons that project from the substantia nigra in the midbrain to the putamen and caudate nuclei, leading to the clinical features of bradykinesia, rigidity, and rest tremor

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Current pharmacological strategies for UC primarily include 5-aminosalicylic acid (5-ASA), glucocorticoids, thiopurines, biological medications, and anti-cytokine therapies (Lamb et al., 2019

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