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Rapid weight loss increases the risk of gallstones, muscle loss, and nutritional deficiencies

Despite these promising results, TRPV1 knockout mice display contrasting phenotypes with the report of opposite phenotypes

The commentary concluded that, based on current knowledge, patients should not stop taking semaglutide on this account alone, especially given potential increases in morbidity from conditions that are well controlled by semaglutide, potential adverse effects of hyperglycemia caused by abrupt cessation of treatment, and the seemingly low absolute risk of NAION