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The high-MW fractions form a transient occlusive layer on the surface during recovery, holding water and reducing transepidermal water loss in the 24-to-48-hour post-procedure window where the barrier is briefly compromised

(2013) 23:R431435

Methodologically akin to a retrospective cohort analysis, our study differs in that it emulates a target trial by prespecifying the protocol, aligning index date, and using propensity score matching to emulate randomization, thereby reducing immortal-time bias, improving transparency, and aligning real-world evidence generation with clinical trial standards

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