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This creates a different but still powerful combination

The use of second-line ADMs was commonly accompanied by insulin or metformin in 80-90% of cases

These hormones are part of the gut-brain axis, and their respective receptors are often present in the periphery as well as in the brain. Elucidating the pathways and processes through which GLP-1 and similar hormones modulate weight loss may allow for the finetuning and evolution of novel therapeutic interventions against obesity, which, if left unchecked, is expected to impact more than half the worlds human population by 2035

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