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Class B GPCRs typically bind their peptide ligands through a mechanism known as the two-domain model, in which ECD binds to the C-terminal helix of GLP-1, and the transmembrane domain (TMD) binds to the N-terminal region of GLP-1 (3, 4, 5)
Most available evidence comes from laboratory and animal studies, where researchers have observed potential effects on: Tendon healing Ligament repair Muscle recovery Gastrointestinal tissue repair Angiogenesis Inflammatory signaling Although these findings are promising, robust human clinical trials remain limited
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