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Transforming growth factor-beta receptor activation represents another key mechanism underlying GHK-Cu's effects on matrix synthesis and tissue remodeling

JAKs activate the transcription factors of the STAT family which have a crucial role in cellular immunity, differentiation, and proliferation

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Downregulated mRNA expression of GPx was reported in white adipose tissue, while GPx mRNA expression was slightly yet significantly upregulated in the liver of KK-A y mice as compared to C57BL/6 mice (Furukawa et al