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Nevertheless, when applied to stressed cortical neurons with reduced mitochondrial membrane potential, PBM returned the membrane potential to normal, thereby reducing ROS production and excitotoxic Ca 2+ levels (Huang et al., 2013, 2014), where the effects of PBM on mitochondrial function have been found to be both dose and time dependent (Silveira et al., 2019)
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Patients in the bottom quartile had a 9% constipation rate and a 19% diarrhea rate
In addition, a deficiency of vitamin B12 can cause facial signs such as hyperpigmentation (dark spots), vitiligo (white patches where skin loses color), or angular stomatitis (inflammation at the corners of the mouth)
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