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For detailed results and additional information on the comparative effectiveness of all included treatments, please refer to Supplementary Table S2
P values were adjusted for multiple testing using the BenjaminiHochberg post hoc method
Of note, current research investigates nanomedicines to increase -tocopheryl succinate bioavailability before exploring putative benefits in clinical settings (118)
"Centenarians display plasma MOTS-c concentrations significantly higher than age-matched peers, a pattern that closely resembles levels found in individuals decades younger suggesting preserved mitochondrial signaling as a hallmark of exceptional longevity." The connection to cellular senescence deserves further attention here
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