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Here, we demonstrate that the effects of cotadutide in reducing body weight and food intake and improving glucose control are predominantly mediated through Glp-1 signalling, whereas its action on the liver to reduce lipid content, drive glycogen flux and improve mitochondrial turnover and function are directly mediated through Gcg signalling

For example: In a study of Ozempic, people taking 1 mg of semaglutide (a typical dose) reported less hunger, more control over their eating, and fewer food cravings, especially for high-fat foods, at the three-month mark

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