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doi:10.1001/jamainternmed.2024.2525 36
Additionally, it can act as an appetite suppressant, though this side effect is not typically the primary reason people seek it out
While tirzepatide has relatively few direct pharmacokinetic interactions, its pharmacodynamic effects and impact on gastric emptying create important clinical considerations
In Mecp2-deficient mice, NTS neurons show significantly reduced amplitudes and frequencies of sIPSCs and mIPSCs, indicating impaired synaptic transmission, and decreased eIPSC amplitudes, though the paired-pulse ratio (PPR) remains unchanged, suggesting that postsynaptic mechanisms may contribute to the weakening of GABAergic inhibition
