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This proteolytic process results in structural rearrangement of S-protein and allows fusion between the viral envelope and host cell membrane 57,76 , which cumulatively drives an efficient internalization (infection) of SARS-CoV-2 into target host cells 55,77

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This is the core issue of PEGylation causing immunogenicity

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Metformin, conversely, interferes with the calcium-dependent absorption of the B12-Intrinsic Factor complex in the terminal ileum (the end of the small intestine)

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