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Glutathione regulates GPx1 expression during CA1 neuronal death and clasmatodendrosis in the rat Hippocampus following status epilepticus
Initially, NOX2 activation generates significant quantities of H 2 O 2 /O, which subsequently activate key signaling pathways such as MAPK and JNK, leading to nuclear membrane breakdown and chromatin decondensation, culminating in NET formation
Reduced efficacy is another factor
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