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Treating the metabolic conditions becomes part of treating the osteoarthritis. Research has shown that patients with type 2 diabetes are more likely to have severe osteoarthritis as well as a higher likelihood of needing revision surgeries after knee replacements

It is usually well tolerated, but rare serious complications such as VPA-induced hepatotoxicity (VHT) and VPA-induced hyperammonaemic encephalopathy (VHE) may occur in some patients who receive VPA chronically [133]

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This is utilized in traditional medicine to treat benign prostatic hyperplasia