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Thiamine deficiency can affect both the central nervous system (CNS) and peripheral nervous system (PNS), manifesting in various symptoms (, , )
Protocols, doses, and reactions reported below come from published research and self-reported community sources
In the REDEFINE 1 trial, published in the New England Journal of Medicine, participants receiving the combination achieved 20.4% mean body weight reduction at 68 weeks
Intramuscular hydroxocobalamin is first-line treatment in the UK for B12 deficiency with neurological symptoms
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