depression with semaglutide People pre-existing or anxiety were less likely to have mental health worsening while taking a GLP-1 medication, observational Swedish data suggested. https://www.medpagetoday.com/psychiatry/generalpsychiatry/120515 New Data Show Semaglutide's Effects

4 However, a separate medical records analysis suggested that non-diabetic men using semaglutide were slightly more likely to develop low testosterone than those who werent

The concept of incretin effect was first proposed by Creutzfeldt in the 1970s (1, 2), based on the early observations that insulin secretion was two to three times higher after oral glucose intake than that after an isocaloric intravenous glucose administration (35)

Lixisenatide requires a functional gut-vagus nerve-brain axis to trigger insulin secretion in controls and type 2 diabetic mice

The immune system shows sensitivity to both GSH deficiency and excess