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Similarly, ICV pretreatment or peripheral post-treatment with the DEETGE-Cal-Tat peptide was also able to decrease Keap1-Nrf2 interaction in the rat hippocampal CA1 region after global cerebral ischemia (GCI) and, as a consequence, to induce Nrf2 target genes and a powerful neuroprotection of hippocampal-dependent cognitive function after GCI [302]
Dosing information Usual Adult Dose for Obesity: 8 mg orally 3 times a day 30 minutes before meals, OR 15 to 37.5 mg orally once a day before breakfast or 1 to 2 hours after breakfast
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