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Antidotes can also be classified based on their site of action [Table 1]: serological antidotes (e.g., polyvalent antisnake venom [PASV]), physiological or pharmacological antidotes (e.g., atropine for organophosphate poisoning), mechanical or physical antidotes (e.g., AC), and chemical antidotes (e.g., acids or alkalis for neutralizing opposite pH substances)

Human results are not established, and large human trials have not been completed, which is a critical limit to keep in mind

In both mice and humans, two homologs have been identified: CHAC1 and CHAC2

Their action is fast, short-acting, and because they are upstream signaling agents, they tend to be more broadly focus on influencing multiple chemical pathways